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About the Study

CAMEO (Clinical, endoscopic, and imaging outcomes of children newly diagnosed with Crohn’s disease) is a collaborative study being performed at 26 leading pediatric inflammatory bowel disease centers in the United States and Canada. The purpose of CAMEO is to help us understand why some children with Crohn’s disease (CD) treated with a common form of therapy (anti-TNF biologics) heal their intestine and others do not. Anti-TNF biologics block a key inflammatory pathway in the bowel. It is also the most common therapy used for children with moderate to severe disease. Research has shown that early use of anti-TNFs is associated with the most favorable outcomes, including remission.

Watch this short video about the CAMEO study. 
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What Do We Hope to Learn from CAMEO?

We know from years of research with adults and children that if we actually heal the bowel with our therapy then the risks of complications from the Crohn’s disease decrease dramatically. By getting a better understanding of the biology of how the bowel is reacting to the anti-TNF medicine we hope to improve our current therapies and hopefully design newer therapies.

Why is Research Important?

The doctors at your center are amongst the leaders in the United States and Canada in treating Crohn’s disease. They understand that the only way we will improve our therapies, and even one day cure Crohn’s disease, is to learn more about how it affects children and adolescents, and how they respond to our current and future therapies.

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Who is Running This Study?

CAMEO has assembled a group of the leading doctors and scientists in North America who care for children with Crohn’s disease and are dedicated to finding better therapies, and one day a cure. This group is led by several doctors who have successfully conducted a similar study of children newly diagnosed with ulcerative colitis. The University of North Carolina Collaborative Studies Coordinating Center is housing all study data and assisting with data analyses. Connecticut Children’s is coordinating the clinical study. Emory University is serving as the biorepository where all specimens are catalogued and stored. Cincinnati Children’s Hospital Medical Center is performing many of the scientific studies along with Emory. The National Institutes of Health (NIH) is funding the study and providing oversight.

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Clinical, Imaging, and Endoscopic Outcomes Of Children Newly Diagnosed with Crohn's Disease